Desembocadura de Río Grande is a municipality of the South Caribbean Coast Autonomous Region in the Republic of Nicaragua.

In the mid-seventeenth century, the different ethnic groups of the Caribbean Coast of Nicaragua were militarily dominated and subordinated by the Miskitos allied with English pirates, thanks to their numerical superiority and having firearms provided by the latter.

In the early twentieth century, American banana and timber companies settled in the region, and the ruins of the machinery they used and later abandoned are still preserved.

In the 1950s, the last enclave companies left, and from then on, the local economy became subsistence-based, based on hunting, fishing, and subsistence agriculture.

The municipality is mainly located on the Atlantic Coastal Plain, characterized by a dominant relief that is flat to strongly undulating, with slopes that fluctuate between 0 and 15%.