These are (number as in the map in the infobox):[2] Karditsa was created as a prefecture (Greek: Νομός Καρδίτσας) in 1899, and again in 1947.

The prefecture was later rebuilt and received electricity, appliances and motorised transport, while emigration also began in the 1950s, when construction of Lake Plastiras was added.

The city is also an important knowledge centre, supporting the Faculty of Veterinary Medicine, the Public and Community Health, Forestry and Wood Sciences, and Science of Foods and Nutrition, departments of the University of Thessaly.

Archbishops: Athletes: Military: Politicians: Singers: Others: Antigoni Drisbioti, Helena Paparizou, Dimitris Mitropanos, Fotini Velesiotu, Dionisis Tsaknis, Kostas Kafasis, Konstantinos Thanos, Ioannis Bourousis, Nina Kaloutsa, Sakis Tsiolis, Vaios Karagiannis, Mimis Gkioulekas, Charilaos Florakis, G.Mpaltadoros, G.Siantos, N. Plastiras, There are a number of highways E75 and the main railway from Volos to Meteora crosses Thessaly.

The region is directly linked to the rest of Europe through International Airport of Central Greece located in Nea Anchialos in a small distance from Karditsa.