Karen Kristine Holtsmark (11 November 1907 – 7 March 1998) was a Norwegian painter.
She was a daughter of Gabriel Gabrielsen Holtsmark (1867–1954) and his wife Margrete Weisse (1871–1933).
Her most important teacher was Axel Revold, and she was also influenced by Vilhelm Bjerke-Petersen to take up the Surrealist style.
She also became a Communist and stayed several times in France where she also studied under Georg Jacobsen in 1936.
[2] In 1932 Holtsmark participated in a group exhibition at the Kunstnerforbundet in Oslo with Bjarne Rise, Johannes Rian and Vilhelm Bjerke-Petersen.