Karen Maine (born June 15, 1985) is an American film director and screenwriter known for Obvious Child and Yes, God, Yes.

The film is based on Maine's experiences growing up in Iowa and attending Catholic school for 15 years, where she received a sex-ed curriculum that emphasized not having sex before marriage.

[3][4][5] Yes, God, Yes premiered at the 2019 SXSW Film Festival and won a Special Jury Award for Best Ensemble.

Richard Brody of The New Yorker said that "Maine uses meticulously composed yet freely imaginative visual and sonic textures to develop the film into a vivid, varied comedic drama and an intricate portrayal of inner experience", Katie Walsh of the Los Angeles Times said that "Maine's film captures something indelible about adolescent female desire, without condescending or objectifying, because she understands, subjectively, what that looks and feels like: all the confusion and shame, but yes, also the pleasure", and Richard Roeper of The Chicago Sun-Times wrote Yes, God, Yes "retains a breezy and upbeat and even sweet disposition, thanks to the light touch of writer-director Karen Maine and an absolutely winning performance by Stranger Things star Natalia Dyer.

[14] Maine directed the pilot and the first season of the BBC Three/HBO Max series Starstruck, created by and starring New Zealand comedian Rose Matafeo.