Karene is one of the sixteen districts that make up the Republic of Sierra Leone.

The capital and largest city of Karene District is Kamakwie[2] Karene along with Falaba District are the two new districts of Sierra Leone formed in December 2017, after they were ratified by the Sierra Leone Parliament in the government of former president Ernest Bai Koroma[3] The major economic activity in Karene is farming.

The Temne people is the predominant majority ethnic group in Karene.

Prior to the 2017 local administrative reorganization, Libeisaygahun, Sanda Loko, Sanda Tenraren, Sella Limba and Tambakha Chiefdoms were formerly from Bombali District; and were Buya Romende, Debia and Sanda Magbolontor Chiefdoms were formerly from Port Loko District.

This Sierra Leone location article is a stub.