She is known for her time as hostess of the MTV game show Remote Control (1988–1989), her portrayals of Abigail on USA Network's Swamp Thing (1991–1992), and Maggie Beckett on the Fox/Syfy series Sliders (1997–2000).

Wuhrer has appeared in horror films such as Anaconda (1997), Eight Legged Freaks (2002), King of the Ants (2003), The Hitcher II: I've Been Waiting (2003), Hellraiser: Deader (2005), two entries in the Prophecy series (both 2005), and Sharknado 2: The Second One (2014).

She portrayed Agent Tanya in cutscenes of Westwood Studios' real-time strategy video game Command & Conquer: Red Alert 2 and its subsequent expansion pack, Yuri's Revenge.

In 1995, she also had a supporting role in the John Singleton film Higher Learning, followed by Thinner (1996), Anaconda (1997), and Kissing a Fool (1998).

[2][6] She was an executive producer of the direct-to-video film Spider's Web, with Stephen Baldwin, of which Wuhrer said: "The pace of making this movie, it was extreme.

[7] Wuhrer is also known by gamers for her role as Agent Tanya in cutscenes of Westwood Studios' real-time strategy video game Command & Conquer: Red Alert 2 and its subsequent expansion pack, Yuri's Revenge.

[8] She posed seminude in Playboy in August 2000 as their Babe of the Month and earlier considered multiple offers to appear fully nude throughout 1998.