Karim Khalili (Persian: کریم خلیلی; born 1950) is an Afghan politician serving as leader of the Hezb-e Wahdat Islami Afghanistan party.

[1] Most recently he was Chief of the Afghan High Peace Council from 2017 until its dissolvement in 2019.

[2] He was selected as a candidate for Second Vice President of Afghanistan in 2002 by Hamid Karzai; they were elected in 2004 and left office in 2014.

[8][9] He attended religious schools during his childhood and moved to Kabul in 1970 to continue his education.

[11] He has two sons, the older of which is Mohammad Taqi Khalili, Afghanistan's Ambassador to Azerbaijan.