Karl Friedrich von Savigny (19 September 1814 – 11 February 1875) was a Prussian diplomat, politician, and a leading member of the Centre Party.
In 1849 he was Councillor of legations and member of the Ministry of Foreign Affairs, and in 1850 ambassador at Karlsruhe (the capital of the Grand Duchy of Baden).
From 1859 Karl Friedrich was Prussian ambassador at Dresden (to the Kingdom of Saxony), from 1862 at Brussels (to Belgium), and from 1864 he was minister with full powers at the Diet of the German Confederation at Frankfurt.
In 1866 he offered at the Diet the Prussian motion for the reform of the German Confederation, and when it was rejected on 14 June 1866, he declared the withdrawal of Prussia, after which the Austro-Prussian War began.
Later in connection with Bismarck he was plenipotentiary in making a treaty of peace with the states of southern Germany and Saxony.