The Karlskirche is a church in Zweibrücken built in 1715, destroyed in 1945, rebuilt in 1970.
[1] It is one of two landmarks of the town with Alexander's Church (Alexanderskirche [de], built 1493–1514).
[2] It was court church from 1733 to 1858.
Its congregation forms part of today's United Evangelical Church of the Palatinate.