The original building was a two-story timbered house, but a new brick building was inaugurated 17 years later in 1901, near Karlskoga Church.

The decision to construct a new healthcare facility was made in 1899 because the former one lacked capacity.

[3] The hospital employs approximately 730 people and serves as an emergency hospital for the western part of Örebro County, the municipalities of Karlskoga and Degerfors, as well as the eastern part of Värmland County, including the municipalities of Kristinehamn, Storfors, and Filipstad.

Karlskoga Hospital consists of six clinics and has 130 beds.

The birthing center at Karlskoga Hospital was shut down in 2019.