The Genaldon river (Terek basin) of the Greater Caucasus mountain system flows in the gorge.

There are geothermal springs and mineral water outlets in the gorge and it serves as a place of rest for the residents of Vladikavkaz.

A popular climbing route to Mount Kazbek passes through the Karmadon gorge along the Mayli glacier.

A mass of snow, ice and stones moved along the gorge at a speed of over 180 km/h.

As a result of the glacier's descent, the village of Verkhny Karmadon was completely destroyed, around 140 people died, including the film crew of the film "The Messenger", led by Sergei Bodrov Jr.[1][2]