The mouth of the river hosts the Port of Chattogram, the largest and busiest seaport of Bangladesh.

The Chittagong Metropolitan Area has a populace of more than 8.9 million,[5] making it the second biggest city in Bangladesh.

[6] Tlabung is situated on the banks of the Karnaphuli River in Lunglei district, Mizoram.

Karnaphuli River links Mizoram with the port cit of Chittagong on the shores of Bay of Bengal.

British Troops and missionaries used this route to reach Mizoram during the Colonial days.

CCCC received $706 million for its services, with total costs expected to be over $1 billion.