Karnafuli Fertiliser Company or KAFCO is a joint venture multinational company located in Chittagong, Bangladesh that produces urea fertiliser from Natural Gas.

It is located in Anwara upazila of Chittagong district by the side of the Karnafuli river occupying an area of 100.03 acres.

An agreement was signed by the Government of Bangladesh, Swiss Agency for Development and Cooperation, and Haldor Topsøe to establish the plant.

The project lacked momentum till the government of Japan agreed to finance it.

On 16 November 1994, construction of the plant was completed and operations started in December 1994.