Karns City Area Junior/Senior High School is located in Karns City, Pennsylvania.

[3] It is part of the Karns City Area School District.

The boroughs of Chicora, East Brady, Fairview, Karns City, Petrolia, and Bruin, as well as the townships of Parker, Fairview, Donegal, Perry, Sugarcreek, Brady's Bend, and Brady are within Karns City School District boundaries.

The school colors are purple and gold.

The school mascot is the Gremlin.