After 1.1 kilometres (0.68 mi) the road reaches a traffic light intersection at Marmion Avenue (north) and West Coast Highway (south), at which point Tourist Drive 204 turns southbound on West Coast Highway, and Karrinyup Road gains the State Route 76 allocation.

The road then travels along the vicinity of the shopping centre and Karrinyup bus station before reaching Francis Avenue 500 metres (1,600 ft) later.

Karrinyup Road reaches Main Street in Balcatta 800 metres (2,600 ft), at which point it continues east as Morley Drive.

Prior to the freeway's construction, this location was the intersection of Odin Road between Innaloo and the Balcatta industrial area.

The entire length of Karrinyup Road falls within the City of Stirling, with all intersections controlled by traffic lights unless otherwise indicated.