The road is part of State Route 76, which connects the coastal suburb of Trigg, Western Australia, with the Swan Valley in the east.

900 metres (3,000 ft) further east, Morley Drive meets Wanneroo Road and then travels along the suburbs of Nollamara and Yokine for 1.1 kilometres (0.68 mi) before intersecting with Flinders Street.

The roads runs through the suburb for 2.8 kilometres (1.7 mi), intersecting with McGilvray Avenue and Crimea Street, before ending at a roundabout interchange at Tonkin Highway.

Apart from minor modifications, Morley Drive remained relatively unchanged until 2010, when the terrain of the eastbound carriageway near McGilvray Avenue was lowered to improve road safety around that area.

2016, the Flinders Street intersection was upgraded with longer turning lanes and better pedestrian facilities.