[a] Born and raised in Manila, Philippines, Karylle first ventured into theater musical in 2000 and played several supporting roles in film and television.

She returned to stage and appeared in two major productions: Cat in the Hat (2007) and West Side Story (2008), garnering praises from the critics.

In 2010, she played a supporting role in the horror film Dalaw and became one of the mainstay host of the long-running noontime show It's Showtime the following year.

Philanthropically, she has been active in supporting the Philippine Animal Welfare Society (PAWS) and charity organizations like White Cross Orphanage and ChildHaus.

Initially scheduled for only a week, the show's producers were impressed with the chemistry between Karylle and actor Dingdong Dantes, leading them to ask her to take on another character, Jade.

[21][22] In this series, she portrayed Cathy Ruiz, an Ilonggo from Guimaras, earning her a nomination for Outstanding Lead Actress at the 2nd Golden Screen TV Awards.

She then starred in the fantasy drama series Enacantadia as Sang'gre Alena, alongside Iza Calzado, Dingdong Dantes, Sunshine Dizon, Jennylyn Mercado, and Diana Zubiri.

Karylle reprised her role in the sequel series Etheria and the crossover film Mulawin: The Movie, both released later in the year.

She then played the female lead role of Maria on the Stages production of the popular musical West Side Story, alternating with Joanna Ampil.

[21][32] She signed her ABS-CBN contract shortly after an appearance in the Oscar De La Hoya vs. Manny Pacquiao boxing match in Las Vegas, Nevada, where she sang the Philippine national anthem.

[38] In 2010, Karylle joined Bangs Garcia, Rayver Cruz, and Sid Lucero in Gilda Olvidado's Magkano ang Iyong Dangal?.

[41] In 2011, Karylle officially became a regular host for Showtime, joining Kim Atienza, Teddy Corpuz, Anne Curtis, Vice Ganda, Jugs Jugueta, Vhong Navarro, and fellow newcomer Billy Crawford.

[44] The series was highly successful, with the cast winning the Bronze Medal for Best Performance at the New York Festivals TV & Film Awards.

[5] Karylle's role as Maddie Avilon earned her a nomination for Outstanding Actress in a Drama Series at the Monte-Carlo Television Festival's Golden Nymph Awards held in Monaco.

[46] Later that year, Karylle also starred with her frequent collaborator Christian Bautista in a critically acclaimed staging of Rama, Hari at the Cultural Center of the Philippines.

[49] In 2013, Karylle top billed a new version of Rodgers & Hammerstein's Cinderella at the Newport Performing Arts Theater in Resorts World Manila.

[6][7][60] In 2021, Karylle appeared in the romantic comedy television miniseries B&B: The Story of the Battle of Brody & Brandy, starring Iza Calzado and Ian Veneracion.

[61] In 2022, Karylle top billed the Repertory Philippines production of Rodgers and Hammerstein's musical Carousel, opposite Gian Magdangal.

[66][67] She then participated in the musical concert Contra Mundum: Ang All-star Concert ng Ang Larawan held at the Manila Metropolitan Theater;[68][69] starred in the musical play Isang Gabi ng Sarsuwela;[70] and reprised her role as Sita in a restaging of the rock opera ballet Rama, Hari.

[74][75] In 2024, Karylle headlined the Manila staging of the Broadway musical Little Shop of Horrors, opposite Nyoy Volante and alternating with Sue Ramirez.

[82] The album also includes two collaborations: "Calling" with German singer Gil Ofarim, and "Kung Mawawala Ka" with Ogie Alcasid.

[88] The album garnered her a nomination for Favorite Female Artist at the 5th Myx Music Awards and was certified Platinum by the Philippine Association of the Record Industry.

[91] Its lead single, "OMG", was featured in the American reality television series, Floribama Shore; and was nominated for Best Dance Recording at the 25th Awit Awards.

[92] In 2013, Karylle released "Sa’yo Na Lang Ako", an official entry for the year's Philippine Popular Music Festival.

[96] Additionally, the album includes the song "Paano ko Tuturuan ang Puso", which was nominated for Best Performance by a Female Recording Artist at the 29th Awit Awards.

[3] In 2020, Karylle released The Holy Rosary: Roses for Mary, a spoken word recording of rosary-based prayers, which also included two religious songs.

[114][115] Karylle has appeared in various endorsements for brands such as Ever Bilena, Bench Body, Santé Barley,[116] Fruitas, Adidas,[117] Belo Medical Group, UniSilver, Status Hair Salon, and OraCare.

[1] After her move to ABS-CBN, it came as a surprise to everyone when Karylle became an endorser for the clothing brand Bench, with her billboards seen all over the Metro Manila for the ad "Single is Sexy!"

Media outlets speculated that Dantes had been unfaithful to Karylle with his Marimar co-star Marian Rivera, with whom he began a relationship soon after the split.

[127] On March 21, 2014, Karylle was married to Sponge Cola vocalist Yael Yuzon at San Antonio de Padua Church in Pooc, Silang, Cavite after dating for over three years.