[4] Attending Yale University, Grace broke four school records, won six Heps championships (one as a member of a relay team), and was a four-time NCAA Division I Track and Field and Cross country All-American.

[9] Grace joined the New Jersey-New York Track Club in 2011, training under legendary coach Frank "Gags" Gagliano.

[16] While working with Gagliano, Grace continued to improve her times on the track and won the 2013 USA road mile championship — her first national title.

Grace ran 4:06.75 in the 1500 meters at the 2016 New Balance Indoor Grand Prix – a time qualifier for Athletics at the 2016 Summer Olympics.

Grace was second in the New York Armory Women's Mile Elite – New Balance Games 2016 after leading teammate Kim Conley for 1500 meters.

[23] Grace improved her personal best to 1:58.28 at Weltklasse Zürich of 2016 IAAF Diamond League in a fifth-place finish.

Grace scored nine points to help Team USA win in Minsk at Dinamo National Olympic Stadium.

In early 2021, Grace announced her departure from Bowerman Track Club on Instagram and soon after joined Team Boss, coached by Joe Bosshard.

However, she won the 800m Wanda Diamond League in Oslo,[32] won the Millicent Fawcett Mile in Gateshead, ran three personal bests over the course of the summer in the 800 m,[31] got second place in the Wanda Diamond League Final, and finished the year in third place in the World Athletics rankings for the event in her most successful season to date.

[33] After a nearly a three year hiatus from competition due to long COVID and pregnancy, Grace returned to racing in 2024.