[1][2] She started directing, writing, and editing several short films including Night Taxi (2008), Waiting Room (2009), Doppleganger (2009), The Park (2010), Illusive Fields (2012), and Breaking News (2018).
[3] In 2015, Katharine O'Brien co-wrote her feature film debut The Automatic Hate, starring Joseph Cross.
The film had its world premiere at South by Southwest on May 14, 2015,[4] followed by a worldwide theatrical release on March 11, 2016.
[5] In 2019, O'Brien directed and wrote Lost Transmissions, starring Simon Pegg.
[10] At the 2020 Prague Independent Film Festival, Katherine won the Grand Prix for Lost Transmissions.