[3] At the time of her appointment, the American Bar Association rated Mizelle "Not Qualified" to serve as a federal trial court judge.

[5][6][7] Upon graduating from law school, Mizelle served as a law clerk to Judge James S. Moody Jr. of the United States District Court for the Middle District of Florida from 2012 to 2013 and to Judge William H. Pryor Jr. of the United States Court of Appeals for the Eleventh Circuit from 2013 to 2014.

[2][9] Before becoming a judge, Mizelle was an associate at Jones Day from 2019 to 2020,[10] where she worked on civil and criminal litigation and appeals.

[13][14][3] On September 8, 2020, her nomination was sent to the Senate to fill the seat vacated by Judge Virginia M. Hernandez Covington, who assumed senior status on July 12, 2020.

The ABA said Mizelle "has a very keen intellect, a strong work ethic and an impressive resume... her integrity and demeanor are not in question.

"[18] But, the committee wrote, "These attributes... simply do not compensate for the short time she has actually practiced law and her lack of meaningful trial experience.

[24] Mizelle also stated that the CDC improperly invoked the good faith exception to the Administrative Procedure Act's notice-and-comment rulemaking process.

[28] On January 12, 2024, Mizelle ruled that prohibiting the possession of firearms in post offices is unconstitutional, citing New York State Rifle & Pistol Association, Inc. v.