Wetherell was born on August 26, 1970, in Daytona Beach, Florida to a politically active family.

[2] Wetherell spent four years in private practice at the Tallahassee firm Hopping Green Sams & Smith, where his practice focused on representing landowners and real estate developers on land use matters before local governments and state agencies and representing corporate clients in administrative rule challenge and bid protest hearings.

[2] Wetherell served for seven years as an Administrative Law Judge of the Florida Division of Administrative Hearings, where he heard a wide variety of cases, involving rule challenges, bid protests, hospital certificates of need, environmental permit challenges, employment discrimination claims, and professional license disputes.

He was nominated to the seat vacated by Judge John Richard Smoak Jr., who assumed senior status on December 31, 2015.

[4] On January 3, 2019, his nomination was returned to the President under Rule XXXI, Paragraph 6 of the United States Senate.