Kawakami Gensai (河上 彦斎, 25 December 1834 – 13 January 1872) was a Japanese samurai of the late Edo period.
At age 16 he was called to serve in the Kumamoto castle town as a menial in charge of cleaning (Osōji-bōzu お掃除坊主).
Although this was a low-level position, Gensai devoted himself wholeheartedly to it, using his free time to polish his martial and literary skills, as well as learn sadō (tea ceremony) and ikebana (flower arrangement).
It was at this time that he met two men who were later important in the activities of the Ishin Shishi: Todoroki Buhē and Miyabe Teizō.
After the political event of Higo-han, he left there and went to Chōshū-han, where he became a personal body guard of Sanjō Sanetomi.
Together with at least three other assassins, they ambushed and attacked Shōzan in broad daylight on 12 August 1864, and ended with Gensai killing him in one stroke.
He changed his name to Kouda Genbei (高田 源兵衛), and served as a military official and sword teacher for the Kumamoto domain.
Because of his harboring of some Kiheitai stragglers under his old comrade Oraku Gentarō, he was arrested in November 1870 and later transferred to a prison in Tokyo in 1871.