Her notable work includes Tholi Prema (1998), Pyaar Ishq Aur Mohabbat (2001) and Arjun (2004).
In 1998, Keerthi was cast as female lead opposite Pawan Kalyan in Tholi Prema which was a blockbuster.
In 2000, Keerthi Reddy made her Bollywood debut in Tera Jadoo Chal Gayaa opposite Abhishek Bachchan.
Her next film Pyaar Ishq Aur Mohabbat featured her as Isha Nair opposite the debutant Arjun Rampal.
Her role was that of a girl who was loved by three men Gaurav Saxena, Yash Sabarwal (Suniel Shetty) and Taj Bharadwaj (Aftab Shivdasani).