He played college football at Arizona Western before transferring to South Carolina, and was signed by the Oakland Raiders as an undrafted free agent in 2019.

Nixon grew up in Compton, California and attended Salesian High School in Los Angeles, where he ran track and played running back and cornerback on the football team.

[7] Nixon finished his rookie season with 12 tackles, one pass defended and three kickoffs returned for 63 yards in 14 games played.

[11] On September 25, 2022, in his second game on the active roster for the Packers, Nixon recorded seven combined tackles and one forced fumble in a Week 3 victory over the Tampa Bay Buccaneers.

[13] On January 1, 2023, Nixon returned a kickoff 105 yards for his first NFL touchdown against the Minnesota Vikings, swinging the game's momentum in the Packers' favor and propelling them to a 41–17 victory that kept their playoff hopes alive.

[15] Nixon finished the season as the NFL's leading kick returner, and was named a first-team member of the 2022 All-Pro Team at that position, receiving 44 out of 50 first-place votes.

[17] Packers head coach Matt LaFleur told reporters during the offseason that he was exploring ways to utilize Nixon on the offensive side of the ball.