Keiser is a city in Mississippi County, Arkansas, United States.

[3] Originally known as "Savage Crossing", Keiser was one of several cities established by prominent late-19th century planter and land developer Robert E. Lee Wilson.

After the forests had been cleared, the city transitioned from a logging town to an agrarian community.

The city is concentrated along a stretch of Arkansas Highway 181, 9 miles (14 km) southwest of Osceola and the same distance northwest of Wilson.

Interstate 55 passes just southeast of the city, with access from Exit 44 (Highway 181).

According to the United States Census Bureau, the city has a total area of 0.4 square miles (1.0 km2), all land.

[1] The climate in this area is characterized by hot, humid summers and generally mild to cool winters.