In the 1960s, Kellenberg commissioned the construction of four diocesan high schools, including Maria Regina in Uniondale.

[5] In September, 1987, the administration of Kellenberg Memorial High School announced the establishment of the Bro.

The main courtyard is located in the center of the building and contains a koi river, four bridges, and a central bell tower.

Students in grades 7 and 8 are required to take Latin, with those who remain at Kellenberg for high school placed in accelerated classes.

Students who graduate from the program are guaranteed admission to the high school; however, they are required to take the CHSEE for statistical and quality-assurance purposes.

Many members of the Society of Mary have canine companions that often follow them to the classroom or reside in their offices during the day, sometimes cited as a very likable trait of the school.

Administrators have contributed articles to a diverse range of publications, from the religious Catalyst to the mainstream New York Times.

[14][15] Former faculty members contributed to works still included in the school's curriculum, from history classes[16] to faith-based clubs.

[18] In the Marianist tradition, many students join sodality groups to mutually reinforce their Catholic faith.

The school also operates Emmanuel, a Marianist Retreat House devoted to students' spiritual formation.

In 2006, the school received national attention when the principal, Kenneth Hoagland, canceled the Senior Prom.

In a letter from late March 2006, he cited "booze cruises" sponsored by parents, cocktail parties, and the film American Pie as examples of "adolescent culture being formed and led by the media".

[22][23] The school received national attention from ABC,[24] CNN,[25] Fox News,[26] MTV,[27] The New York Times,[28] and Comedy Central's The Colbert Report.