The series follows Bureau Chief Tracey Kibre (Bebe Neuwirth), an Executive Assistant District Attorney assigned to Manhattan's homicide division.

Kibre's plea for justice veers suddenly when evidence indicates the killer might be a federal agent's snitch, while she also fears the jury will sympathize when they see the bandaged man wheeled into court for his trial.

Kibre and Gaffney face the unpopular job of prosecuting a father (Aidan Gillen) accused of murdering a paroled child molester who had approached his daughter.

Kibre and Gaffney must regain their footing before the jury through old-fashioned detective work, which reveals critical holes in the murderer's persistent claim that he has been victimized by everyone.

Kibre prosecutes an elusive career criminal Shane Lucas (Ritchie Coster) for the murder of a sleazy ex-cop and the shooting of Detective Ed Green.

When a sting goes bad and a shocking courtroom development cuts the legs from under her case, Kibre's career teeters on finding why the shootings were committed in the first place.

ADA Kibre works to prosecute a serial rapist (Alfred Molina), whose trail of victims through the years has been whitewashed by his wealthy and protective mother (Angela Lansbury).

The rival CBS procedural Numbers debuted in the midseason in late January 2005 and consistently beat NBC's Medical Investigation in the ratings, sending the latter show into hiatus and eventual cancellation, freeing up the time slot for Law & Order: Trial by Jury.

[citation needed] On April 25, 2006, Universal Studios Home Entertainment released Law & Order: Trial by Jury – The Complete Series on DVD in Region 1.