Greenberg played basketball, field hockey, and softball at Archbishop Wood High School in Philadelphia.
32 jersey was retired, joining just three other female athletes: former WNBA player Debbie Black, Kathy May Greenberg, Kelly's sister, and Joanne Healy.
[citation needed] Greenberg was a two-time second-team All-Big 5 selection at La Salle University, leading the Explorers to three consecutive Big 5 Championships and NCAA tournaments.
During the season, the team won a program-record 21 consecutive games, which ranked as the longest active winning streak in the nation at the time.
After guiding Penn to two Ivy League championships during her five-year tenure, Greenberg was appointed head coach of the Boston University women's basketball program on July 7, 2004.
In 2005–06, Greenberg led her Terrier team to an 18–12 record and an appearance in the America East tournament title game following a 76–74 overtime victory over second-seeded Stony Brook in the semifinal round.
In 2014, Greenberg resigned as head women’s basketball coach after multiple players reported systematic abuse.