KY 224 begins at a junction with U.S. Route 62 (US 62) in Clarkson, in Grayson County.

It also has a junction with the Wendell H. Ford Western Kentucky Parkway at exit 112.

The highway briefly runs through the northwesternmost part of Hart County, and enters southern Hardin County about three miles (4.8 km) later and intersects US 31W (Dixie Highway) at Upton.

KY 224 joins US 31W for about 0.4 miles (0.64 km) and enters LaRue County just before leaving the U.S. Route.

KY 224 crosses the exit 76 interchange of Interstate 65 (I-65) and ends at a junction with KY 357 in rural southern LaRue County east of Upton and southwest of Hodgenville.