Kentucky Route 43 (KY 43) is a state highway in Kentucky that runs from BUS KY 55 and Boone Station Road northeast of Shelbyville to U.S. Route 421 (US 421) southeast of Pleasureville.

The road passes through a mix of farmland and woodland with some homes, running to the north of a R.J. Corman Railroad line.

Here, the route turns north to remain on Cropper Road, passing through more agricultural areas with some woods.

The road turns east before a curve back to the north as it continues through more rural areas.

The route continues through more farmland with some trees and comes to a junction with the northern terminus of KY 395.