It continues north-northwestwardly into eastern Nelson County, providing access to the Bluegrass Parkway and US 62 at Bloomfield.

In Finchville the route is lined with houses and a few businesses, and the speed limited is reduced to 35 MPH.

A 1,000,000 sqft battery factory developed by a California-based company, a distillery aiming to boost tourism related to the bourbon trail project and several smaller businesses have recently popped up just south of the I-64 exit#32 on the eastern side of the highway.

[3] The Shelbyville Bypass runs north then curves east, crossing KY 53 near Shelby County West Middle School.

The route continues east, crossing over Clear Creek and ends north of Shelbyville at an intersection with KY 55 Business.

After passing by Henry County High School and traveling through New Castle, US 421 and KY 55 split in Campbellsburg.

Roughly 2.5 miles (4.0 km) north of US 421, KY 55 passes over Interstate 71 and enters into Trimble County, where it travels for a short distance.

After the intersection with KY 389, the route turns toward the northwest and travels along the Kentucky River on the east, with mainly woods on the west.

As it nears Presntonville, KY 55 turns toward the west, then northeast, then north at New Castle Pike.

The route runs north from its southern terminus and passes over the Cumberland Expresway as it enters Columbia.

From its origin, it passes through a commercial area of Shelbyville with many businesses and shopping centers lining the roadway.

The route then departs with US 60 and KY 53 and turns north and becomes a two-lane highway, passing by multiple businesses and subdivisions.