Most of its length is in the city limits of Fort Thomas, though the eastern segment is on the northern edges of Cold Spring.

After crossing under I-275, it turns west along River Road and continues into Fort Thomas.

It passes the Tower Park Soccer Field and curves to the west-northwest.

When KY 445 splits off, it travels to the west-northwest and meets its eastern terminus, an intersection with U.S. Route 27 (US 27; Alexandria Pike).

This intersection is on the eastern edge of the Highland Country Club golf course.