The eastern terminus is at KY 234 near the community of Indian Hills east of downtown.

From its starting point, KY 880 ran approximately 3.6 miles (5.8 km) around the northwestern outskirts of Bowling Green, intersecting Kentucky Route 2665 (Glen Lily Road) ahead of a junction with U.S. Route 231.

The concurrent routes, collectively named Campbell Lane, ran for five miles (8 km) around the southern portion of Bowling Green, passing through one of the main commercial districts of the city.

The routes remained overlapped to another intersection with US 231 Business, where US 231 separated from the loop and followed its previous alignment south out of the city onto Scottsville Road.

Starting at a junction with US 231 and US 231 business, KY 880 runs to the northeast for approximately three miles as Lovers Lane until reaching its eastern terminus at KY 234, less than a mile from the Exit 26 interchange of Interstate 65.