Blankenbaker Parkway originates at a junction with KY 155 in a residential area east of Jeffersontown.

It travels northward as a divided two-lane road before becoming a four-lane divided roadway as it curves toward the northeast at a junction with KY 913 Spur.

Blankenbaker Parkway then curves back toward the north and passes through an industrial area.

After forming a junction with Plantside Drive, Blankenbaker Parkway becomes three lanes in both directions, passing through a commercial area with many businesses, restaurants, and hotels lining the roadway.

After passing over I-64, Blankenbaker Parkway narrows to two lanes in both directions and passes by the main campus of Southeast Christian Church, one of the largest churches in the United States.