Kershaw is a town in Lancaster County, South Carolina, United States.

The Dr. William Columbus Cauthen House, Clinton AME Zion Church, East Richland Street-East Church Street Historic District, Kershaw Depot, Matson Street Historic District, and Unity Baptist Church, are listed on the National Register of Historic Places.

Together the two highways lead south 21 miles (34 km) to Camden.

According to the United States Census Bureau, the town has a total area of 2.1 square miles (5.4 km2), all land.

As of the 2020 United States census, there were 1,693 people, 736 households, and 480 families residing in the town.

There were 771 housing units at an average density of 416.4 per square mile (160.8/km2).