Van Wyck is a town in the panhandle of Lancaster County, South Carolina, United States.

Established in the 1880s, it was to be originally named "Cocheecho", after a young Indian chief, by the Seaboard Air Line Railroad.

An agent of the railroad stepped in and proposed naming the community in honor of his wife's family in upstate New York.

Families who have lived in the area since its founding in the 1880s generally pronounce it "Van Wike".

South Carolina Highway 5 passes through the southern part of the town, terminating to the east at US-521 and leading west 12 miles (19 km) to Rock Hill.