Mirallas spent the last four seasons of his professional career at four different clubs, first returning to his home country with Royal Antwerp.

Mirallas represented Belgium at various youth levels and then went on to earn 60 caps for the senior national team, making his debut in 2007.

[8] Mirallas scored in a 2–1 away loss to their greatest rivals Panathinaikos in the Derby of the eternal enemies, after which his contract was extended to four years.

[15] In his first start four days later, Mirallas scored twice and provided two assists as Everton won 5–0 against Leyton Orient in the second round of the League Cup.

[16] He scored his first league goal on 22 September 2012, in a 3–0 away win against Swansea City after heading in his initial effort which rebounded off the underside of the bar.

He scored his first league brace in David Moyes' last home game in charge of Everton, a 2–0 win against West Ham United.

[19] He also received a booking for a high challenge on Luis Suárez, which opposing manager Brendan Rodgers described as reckless and insisted Mirallas was lucky to remain on the pitch.

[22] On 18 September 2014, Mirallas scored his first European goal for Everton in a 4–1 win over Wolfsburg in the first match of their Europa League campaign.

[28] On 16 April, Mirallas scored a stunning strike from the edge of the penalty area on the stroke of half-time in a 5–1 home win against Kerkyra.

[30] On 4 August 2018, Mirallas signed for Fiorentina on a season-long loan deal with the option to make the transfer permanent.

[37] Mirallas has represented Belgium at under-17, under-19 and under-21 level, and was one of the leading figures in guiding the under-21s to the semi-finals of the 2007 UEFA European Under-21 Football Championship.

He made his tournament debut in the second group match, a 1–0 win over Russia at the Maracanã, as a 75th-minute substitute for Dries Mertens.