Born in Atlanta,[1] Murphy earned four varsity letters in basketball at Creekside High School in Fairburn, Georgia.

In his senior season at Creekside High School, Murphy averaged 26 points, 8 rebounds and 3 assists per game.

[1] In his freshman season at Tennessee Tech, Murphy averaged 9.6 points, 2.9 rebounds, and 1.8 assists per game.

In the Ohio Valley Conference men's basketball tournament, Murphy averaged 24.3 points per game and was named to the All-Tournament Team.

[7] On July 10, 2013, Murphy was involved in a three-team trade that sent him and Andre Iguodala, then of the Denver Nuggets, to the Golden State Warriors.

[27] On September 26, 2018, Murphy signed with the San Miguel Beermen of the Philippine Basketball Association (PBA).

[29] In February 2023, Murphy returned to the Philippines, this time signing with the NorthPort Batang Pier to replace Marcus Weathers as the team's import for the 2023 PBA Governors' Cup.

[31] On April 19, 2024, Murphy made his debut for Al Ahly Ly in the Basketball Africa League (BAL).

[32] In October 2024, Murphy joined another Libyan club in Al Ahli Tripoli,[33] for the 2025 BAL qualification.

On November 9, 2024, he scored 34 points in the decisive victory of Tripoli over the ABC Fighters, which clinched the team's first BAL participation in club history.