He has also played for the Kansas City Chiefs, New York Jets, Chicago Bears, Washington Football Team and Houston Texans.

Pierre-Louis attended King Low Heywood Thomas, a private, co-educational day school in Stamford, Connecticut, where he played middle linebacker and fullback.

In 2012, he started nine games for the Eagles, finishing the season ranked fourth on the team with 85 tackles, including four for loss, two sacks and three pass breakups.

[6] Pierre-Louis made his NFL debut on September 21, 2014, in an overtime win against the Denver Broncos where he recorded one tackle.

[10] On August 11, Pierre-Louis was suspended the first game of the 2018 season for violating the NFL's Policy and Program for Substances of Abuse.

[15] The following week against the Minnesota Vikings, Pierre-Louis recorded his first career interception off a pass thrown by quarterback Sean Mannion during a 21–19 win.

On March 16, 2021, Pierre-Louis signed a two-year contract worth up to $8 million with the Houston Texans.

[24] Pierre-Louis is of Haitian descent; his father is from Léogâne and his mother's family lives in Port-au-Prince.