He played in Major League Baseball (MLB) for the San Diego Padres, Cincinnati Reds, and Los Angeles Dodgers.

[9] On November 8, 2017, Quackenbush signed a minor league deal with the Cincinnati Reds organization.

[11] On November 13, 2018, Quackenbush signed a minor league contract with the Los Angeles Dodgers.

[12] He was assigned to the Triple–A Oklahoma City Dodgers and was selected to the Pacific Coast League team at the Triple-A All-Star Game.

[13] In 54 total appearances for the OKC Dodgers, Quackenbush logged a 5.06 ERA with 85 strikeouts and 11 saves across 58+2⁄3 innings pitched.

[17] He was assigned to the Triple-A Oklahoma City Dodgers to begin the season and was called up to the major leagues on August 7.

On May 2, 2023, Quackenbush signed with the Long Island Ducks of the Atlantic League of Professional Baseball.