Adjacent to this is the Florida Keys National Marine Sanctuary covering 178 square nautical miles.

As of the 2020 United States census, there were 12,447 people, 4,326 households, and 2,692 families residing in the CDP.

The Roman Catholic Archdiocese of Miami formerly operated the Saint Justin Martyr, Academy of Marine Science (PK-9) school in Key Largo.

[11] The 1948 film Key Largo, starring Edward G. Robinson, Lauren Bacall, and Humphrey Bogart, was set there.

The 1981 hit single "Key Largo" by Bertie Higgins was inspired by the film, not the namesake town.

Conversely, the 1984 single "Smooth Operator" by Sade references the town, rather than the film.