Layton is a city located on the island of Long Key in Monroe County, Florida, United States.

By 1910, Layton was becoming famous as a fishing destination, thanks in part to promotion by sportswriter, Zane Grey.

However, the developing tourist infrastructure on Long Key, including a station on the Overseas Railroad, was largely destroyed by the Labor Day Hurricane of 1935.

According to the United States Census Bureau, the city has a total area of 0.22 square miles (0.57 km2).

[8] As of the 2020 United States census, there were 210 people, 55 households, and 28 families residing in the city.

[12] As of the 2010 United States census, there were 184 people, 76 households, and 47 families residing in the city.

As of 2000, English as a first language accounted for 90.68%, while Spanish as a mother tongue made up 9.31% of the population.