The Key Route Inn was a major hotel in Oakland, California in the early decades of the 20th century.

It was constructed by the Realty Syndicate of Francis "Borax" Smith and Frank C. Havens, a subsidiary of which was the Key Route transit system.

[1] The building was a massive wood-framed structure with open timbering, in imitation of an old English style.

[3] This, combined with the beginning of the Great Depression and the City of Oakland's desire to connect Grand Avenue with 22nd Street led to the Inn being fully demolished in April and May, 1932, only 25 years after it opened.

The rail line was replaced by the "B" bus route in April 1958, and was subsequently incorporated into the publicly owned AC Transit system; the modern line B route bypasses the location of the former hotel by nearly a mile.