Keyes is a town in Cimarron County, Oklahoma, United States.

[7] Keyes was also the final destination of the Beaver, Meade and Englewood Railroad, which reached town from the east on June 25, 1931.

According to the United States Census Bureau, the town has a total area of 0.4 square miles (1.0 km2), all land.

Keyes is at the intersection of U.S. Route 56 and the northern terminus of Oklahoma State Highway 171.

[13] As of the 2010 United States Census, there were 324 people, 131 households, and 88 families residing in the town.

[17] The town's location in the Hugoton Friedrich Basin makes it an ideal source for helium production from natural gas.