Keysville is a town in Charlotte County, Virginia, United States.

The two routes together lead southwest 15 miles (24 km) to their split at Wylliesburg.

According to the United States Census Bureau, Keysville has a total area of 1.2 square miles (3.0 km2), all of it land.

An optical fiber link between Farmville and Keysville was the first on the agenda in efforts by Governor Mark Warner to bring broadband internet access to rural areas of Virginia, funded by the Tobacco Indemnification Fund.

This was also accomplished to aid in developing the Southside Industrial Park by bringing mid-sized businesses the technological access needed in an effort to bring more industry to Charlotte County.