In his films, Youssef has addressed the issues of authoritarianism, lack social justice, poverty, religious intolerance, corruption, restrictions on the freedom of thoughts and opinion, and the sexual violence in the Egyptian and the Arab communities.

He participated in students' activities launched relationship between the Director and senior politicians, cultured and creative characters in Egypt, such as Youssef Shahin who advised him to work in cinema when he felt that he enjoys talent.

Therefore, he offered him to know about cinema world through participation in short narrative documentary film "Al Kahira Monwara Beahliha" when an acting personality embodiment was entrusted to him, in addition to training on directing.

In 2001, he directed his second Film "Gwaz Biqarar Gomhoury", and he obtained the reward of best director (Top Work) in the National Festival of the Egyptian Cinema.

In 2007, he participated Director Youssef Shahin in directing "Heya Fawda" Movie, which constituted a rare precedent in the history of the Egyptian cinema.

In the same year (2007), he presented his Movie "Hena Mysara", which sparked controversy not only in Egypt, but also worldwide as it was widely successful at the both criticism and audience admiration levels.

In 2008, he presented "Al Rayis Omar Harb" Movie, and obtained the prize of the Best Director of the National Festival of Egyptian Cinema for the second year respectively.

According to Dubai International Film Festival 2013 two of Khaled Youssef's movies "Heya Fawda" and "Hena Mysara" were in the list of the “100 Best Arab Films of All Times” He was born in a village in Delta Egypt (Kafr Shokr) in 1964 to a father who served as mayor, in addition to being the secretary of Socialist Union at Kafr Shokr (the only political organization founded during the rule of President Gamal Abdelnasser).

His father's relationship with Khalid Mohi Eldin, the member of 23rd Revolution Leadership Council, and one of the main symbols of the leftism and socialism in the Arab world impacted him remarkably in his youth to make him familiar with the outlets of extensive knowledge and considerable experience added to him and contributed to formation of consciousness.

When the Egyptian political system started to follow the policies that enriched the wealthy and impoverished the poor and wasted freedoms, he was in the forefront with other national forces in coping that.

When he began his film career making movies bearing his signature wholly biased for the poor and the marginalized scandalous to their suffering in a manner that reflect the dishonoring of freedoms and human dignity.

Yousuf claimed that Jews still engage in this behavior against Muslims today in fields such as cinema, explaining that "When we would go to the Cannes Festival, they would try to make the Egyptian film fail.