KhizarKhail (خضر خیل) is a clan of Isakhel (sub-tribe) of Pashtun tribe Niazi or Niazai.

Their ancestral village is Khaglan Wala, Isa Khel Tehsil, Mianwali District.

They are also living in Bannu, Khanewal, Sukkur, Hala, Bahawalpur, Karachi, Lahore, Faisalabad Mohalla Khizar Khel and many other area.

Khizar Khan is ancestor of Khizar Khel clan and was Great-great grandson of Isa Khan (Isa Khel (sub-tribe),The earliest recorded mention of the Isa khel Tribe is in Baburnama, 1504-1505).

KhizarKhail clan is mentioned only three times in historical books Hyat i Afghani by Muhammad Hayat Khan Khattar, Niazi Qabely Ki Dastaan and Tareekh-e-Niazi Qabail by Muhammad Iqbal Khan Niazi.