The Khon Kaen National Museum (Thai: พิพิธภัณฑ์แห่งชาติขอนแก่น; RTGS: phiphitthaphan haeng chat khonkaen) was opened by King Bhumibol Adulyadej on 20 December 1972.

Besides the museum's permanent collection, temporary exhibitions are shown throughout the year.

[1] Exhibits in the museum include: The museum gathered its collection from archaeological sites in north and east Thailand, in particular, finds from Ban Chiang in Udon Thani Province, which has been given UNESCO heritage site status.

Isan (or northeastern Thailand), once home to Ban Chiang, Dvaravati, Lopburi and Khmer civilizations.

Among its other exhibits are dinosaur fossils, human skeletal remains, ancient musical instruments, pottery, and Buddha images.