Khoyskis or Khan-Khoyskis is Azerbaijani noble family.

In the late 16th and early 17th centuries, Khoy belonged to the head of the Donboli tribe.

In the XVII-XVIII centuries, the city remained the hereditary land of the head of the Donboli tribe.

The children of Ismayil khan adopted the surname Khoyski, and the children of his brother Abuturab khan adopted the surname Abrakhanov.

The surname Khoyski or Khan-Khoyski, which was formed from the toponym - the Khanate of Khoy - was finally assigned to the representatives of this clan as a surname, apparently, in the 1870-1880s.