80183271221ENSG00000102445ENSMUSG00000034959Q9H714Q3TD16NM_001286765NM_001286766NM_001349772NM_198642NM_001374214NP_001273695NP_079389NP_001336701NP_941044NP_001361143Pacer (also known as Rubicon-like) is a protein that in humans is encoded by the RUBCNL gene.

[5] Pacer has been shown to increase cellular autophagy through regulation of PI3KC3.

[6] Pacer contains a Rubicon homology (RH) domain at its C-terminus, which mediates binding to small GTPase Rab7 when Rab7 is phosphorylated following mitochondrial damage.

[9] Whereas Pacer appears to upregulate autophagic activity, Rubicon is a negative regulator of autophagy.

This article on a gene on human chromosome 13 is a stub.